T cells
2014/9/26 5:23:05 
203 
1Events that occur in rheumatoid arthritis synovial tissues are responsible for the signs and symptoms of joint inflammation and for the eventual destruction of articular and periarticular structures that lead to joint dysfunction and disability. The three most abundant cell populations in RA synovium are synovial macrophages (type A synoviocytes), synovial fibroblasts (type B synoviocytes) and infiltrating T lymphocytes. Other important cell populations include B lymphocytes, dendritic cells, plasma cells, mast cells and osteoclasts. Our current understanding of rheumatoid arthritis is moving beyond previous concepts that view this disease as the consequence of a specific and focused humoral or cellular autoimmune response to a single autoantigen. Rather, a new view of rheumatoid arthritis is emerging, which seeks to understand this disease as the product of pathologic cell-cell interactions occurring within a unique and defined environment, the synovium. T lymphocytes in rheumatoid arthritis synovium interact closely with dendritic cells, the most potent antigen-presenting cell population in the immune system. T cells also interact with monocytes and macrophages and cytokine-activated T cells may be, especially, suited to trigger production of the important cytokine TNFalpha by synovial macrophages. Recent evidence also suggests a potent bidirectional interaction between synovial T cells and synovial fibroblasts, which can lead to activation of both cell types. An important role for synovial B lymphocytes has been emphasized recently, both by experimental data and by results of clinical interventions. B cells in synovium can interact with fibroblasts as well as with other cells of the immune system and their potential role as antigen-presenting cells in the joint is as yet underexplored. Rheumatoid arthritis synovium may be one of the most striking examples of pathologic, organ-specific interactions between immune system cells and resident tissue cell populations. This view of rheumatoid arthritis also leads to the prediction that novel approaches to treatment will more logically target the intercellular communication systems that maintain such interactions, rather than attempt to ablate a single cell population.
无意义的评论将被删除,并扣除相应的积分.
热评图文
用料
鸡翅10只可乐半罐（一罐330毫升）酱油2勺老抽1小勺八角1个桂皮1小块姜 葱各适量米酒1勺(因本人不喜欢料酒味，平时都用米酒去腥）
可乐鸡翅（家常版）的做法步骤
步骤 1
鸡翅洗干净 两面划刀 沥干水份 加一勺酱油 适量姜丝 一小勺米酒 腌制一个小时以上
步骤 2
腌制好的鸡翅冷水下锅 加入葱 姜焯水 煮出浮沫 撇去浮沫 捞出 温水洗净 沥干..
虎皮青椒
用料
青椒5个蒜末2瓣生抽2勺老抽0.5勺醋1勺白糖1勺淀粉1勺油耗油
虎皮青椒的做法步骤
步骤 1
做法： ①调酱汁：2勺生抽+半勺老抽+1勺陈醋+1勺白糖+一勺淀粉+少许清水搅拌均匀。 喜欢耗油的可以再+1勺耗油
步骤 2
②青椒洗净去蒂切段，电炒锅里适量油，放青椒煎出虎皮，放入蒜末，倒入料汁焖煮收汁即可~
..